To understand how the hemodynamic environment within the aneurysm changes as the aneurysm develops and grows, and how these changes differ between aneurysms that rupture and those that remain stable.
Better understand the characteristics that distinguish stable aneurysms from unstable aneurysms that evolve towards rupture. This will impact the clinical practice by better understanding the characteristics of unruptured aneurysms that could be conservatively observed (stable) and those that require immediate treatment (unstable).
We will build computational models of aneurysm evolution (including both ruptured and unruptured aneurysms from our database) and study the changes in the hemodynamic environment at different stages of the evolution. Note that aneurysm evolution is extremely difficult to observe because of the small number of aneurysms considered safe for observation without treatment, also because of the long time required to observe the aneurysm progressing, and because if an aneurysm that is being followed is observed to change (e.g. grow) it is treated immediately. Thus, we propose to build synthetic aneurysm evolution sequences and observe the changes in the aneurysm flow conditions as it progresses towards rupture or stability.
The funds will be primarily used to push forward impactful research studies that are currently unfunded, with the expectation that they will not only have an immediate impact, but also generate preliminary data for future grants.
Specifically, the funds will be used to: a) support faculty efforts to devote time to these research project, b) support travel and collaboration with multiple centers and clinics to conduct joint research, as well as conference publication opportunities to disseminate results and promote the use of the new discoveries and knowledge in the clinic, and c) cover journal paper publication expenses.